Browsing by Author "Pinarbasi, H"
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Genetic polymorphisms of GSTs and their association with primary brain tumor incidence
Pinarbasi, H; Silig, Y; Gurelik, M (ELSEVIER SCIENCE INC, 2005)Glutathione S-transferases GSTM1, GSTT1, and GSTP1 are phase II biotransformation enzymes that function on detoxification of a wide range of exogenous agents including carcinogens. It has been shown that genetic variations ... -
Molecular genotyping of methicillin-resistant Staphylococcus aureus strains in a teaching hospital in Turkey
Oztop, AY; Pinarbasi, H; Kocagoz, S; Bakici, MZ; Bakir, M (MARY ANN LIEBERT INC PUBL, 2004)Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major causes of nosocomial infections in our hospital. Therefore, we aimed to characterize MRSA isolates phenotypically from patients with nosocomial infections ... -
No association of polymorphisms in the glutathione S-transferase genes with pre-eclampsia, eclampsia and HELLP syndrome in a Turkish population
Cetin, M; Pinarbasi, E; Percin, FE; Akgun, E; Percin, S; Pinarbasi, H; Gurlek, F; Cetin, A (BLACKWELL PUBLISHING ASIA, 2005)Aim: There is substantial evidence that genetic factors play a role in pre-eclampsia. The aim of this study was to determine whether genetic variability in the encoding of genes for glutathione S-transferase M1 (GSTM1) and ... -
Polymorphisms of CYP1A1, GSTM1, GSTT1, and prostate cancer risk in Turkish population
Silig, Y; Pinarbasi, H; Gunes, S; Ayan, S; Bagci, H; Cetinkaya, O (TAYLOR & FRANCIS INC, 2006)Prostate cancer is the most common cancer among men in many countries. Although the etiology of prostate cancer largely is unknown, both genetic and environmental factors may be involved. Advanced age, androgen metabolism, ... -
Recombinant alpha and beta subunits of M.AquI constitute an active DNA methyltransferase
Pinarbasi, H; Pinarbasi, E; Hornby, D (SPRINGER SINGAPORE PTE LTD, 2002)AquI DNA methyltransferase, M.AquI, catalyses the transfer of a methyl group from S-adenosyl-L-methionine to the C5 position of the outermost deoxycytidine base in the DNA sequence 5'CYCGRG3'. M.AquI is encoded by two ... -
The small subunit of M center dot AquI is responsible for sequence-specific DNA recognition and binding in the absence of the catalytic domain
Pinarbasi, H; Pinarbasi, E; Hornby, DP (AMER SOC MICROBIOLOGY, 2003)AquI DNA methyltransferase (M (.) AquI) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the CS position of the outermost deoxycytidine base in the DNA sequence 5`-CCCGGG-3'. M (.) AquI is a heterodimer ... -
Strong association between the GSTM1-null genotype and lung cancer in a Turkish population
Pinarbasi, H; Silig, Y; Cetinkaya, O; Seyfikli, Z; Pinarbasi, E (ELSEVIER SCIENCE INC, 2003)Glutathione S-transferases are possibly related to the detoxification of many xenobiotics involved in the etiology of cancer. To investigate the role of the glutathione S-transferase M1 deletion (GSTM1-null) in lung cancer, ...